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KMID : 0363220100480080684
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Korean Journal of Dermatology
2010 Volume.48 No. 8 p.684 ~ p.688
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Blastoid Mantle Cell Lymphoma: A Case Report
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Shin Jung-Woong
Yang Jung-Hoon
Lee Sung-Yul
Lee Jong-Suk
Park Young-Lip
Cho Moon-Kyun
Cho Hyun-Deuk
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Abstract
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Mantle cell lymphoma (MCL) is a low-grade malignant lymphoma derived from a subset of B-cells localized in the mantle zone of the lymphoid follicle. MCL commonly involves extranodal sites, usually as a manifestation of disseminated disease. The immunophenotype of MCL is characterized as CD20＋, CD5＋ and Cyclin D1＋. Blastoid mantle cell lymphoma (BV-MCL) is a rare variant and has a more aggressive clinical course. In the blastoid variant, the genetic profile is often more complex and includes tetraploid chromosomes, CCND1 amplification, a higher incidence of p53 gene mutations, and p16(INK4a) deletions. We report a case of a 62-year-old male patient who presented with erythematous subcutaneous nodules on the lower back. He had been treated for BV-MCL of the testis which had occurred 1 year ago. The analysis of histopathological and immunohistochemical examinations of the skin lesions also revealed a BV-MCL.
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KEYWORD
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Blastoid, Mantle cell Lymphoma, Skin
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